Gt(ROSA)26Sor^{tm1(LDLR)Leyma}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(LDLR)Leyma}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Leyuan Ma
• MGI ID: MGI:8472106
• Synonyms: hLDLR^fl
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(LDLR)Leyma} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:393627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(LDLR)Leyma} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LDLR (3949)

  Ldlr	(MGI:96765)

• Mutation details:

  A single-copy CAG promoter-driven human LDLR (hLDLR) cDNA expression cassette was targeted into the Gt(ROSA)26Sor safe harbor locus by homologous recombination. A loxP-flanked PGK neo selection marker sits between the CAG promoter and the hLDLR ORF, blocking transcription until Cre recombinase excises it. (J:101977, J:393627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:393627 Li J, et al., An inducible human LDLR transgenic mouse model for enhanced lentiviral gene delivery to murine immune cells. Front Immunol. 2026;17
• All: 2 reference(s)