Gt(ROSA)26Sor^{tm1(CAG-Ppif*,-EGFP)Elis}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Ppif*,-EGFP)Elis}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Roman A Eliseev
• MGI ID: MGI:8395650
• Synonyms: R26^caPpif
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Ppif*,-EGFP)Elis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Ppif*,-EGFP)Elis} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppif (MGI:2145814)

• Mutation details:

  The allele was designed to introduce a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a loxP-flanked STOP (PGK-Neo-PGKpA) cassette, an Myc-DDT(Flag) tagged mouse constitutively active K166Q mutant peptidylprolyl isomerase F (cyclophilin F) cDNA (Ppif), followed by an internal ribosome entry site (IRES) and enhanced green fluorescent protein (EGFP) cassette, and polyA signal, all inserted into the Gt(ROSA)26Sor locus. (J:101977, J:344001)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:344001 Sautchuk R, et al., Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation. Elife. 2022 May 30;11:e75023
• All: 5 reference(s)