Gt(ROSA)26Sor^{tm1(CAG-Gsk3b)Ddb}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Gsk3b)Ddb}
• Name: gene trap ROSA 26, Philippe Soriano; argeted mutation 1, Daniel D Billadeau
• MGI ID: MGI:8394334
• Synonyms: Rosa26-LSL-nuclear GSK-3Beta
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Gsk3b)Ddb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324985
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Gsk3b)Ddb} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gsk3b (MGI:1861437)	with a nuclear localization signal and HA tag

• Gt(ROSA)26Sor^{tm1(CAG-Gsk3b)Ddb} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details:

  A construct containing sequence for the CAG promoter, floxed neo-STOP cassette, mouse Gsk3b cDNA, nuclear localization signal, and an HA-tag was inserted via homologous recombination. (J:324985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:324985 Ding L, et al., Nuclear GSK-3beta and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN. Front Cell Dev Biol. 2022;10:853003
• All: 1 reference(s)