Cyfip1^{tm2b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cyfip1^{tm2b(EUCOMM)Wtsi}
• Name: cytoplasmic FMR1 interacting protein 1; targeted mutation 2b, Wellcome Trust Sanger Institute
• MGI ID: MGI:8350093
• Gene: Cyfip1 Location: Chr7:55491556-55582381 bp, + strand Genetic Position: Chr7, 33.42 cM, cytoband B5
• Alliance: Cyfip1^{tm2b(EUCOMM)Wtsi} page
• IMPC: Cyfip1 gene page

Mutation origin

• Mutant Cell Line: EPD0555_2_B11
• Germline Transmission: Earliest citation of germline transmission: J:361968
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 55522828 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 55525323. The critical exon(s) is/are thus flanked by loxP sites. Cre expression occurs without flp expression created a reporter knockout allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:361968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyfip1 Mutation: 74 strains or lines available

References

• Original: J:361968 Mary Lyon Centre at MRC Harwell, Direct data submission from Mary Lyon Centre at MRC Harwell. 2025
• All: 1 reference(s)