Gt(ROSA)26Sor^{em1(CAG-Snca/EGFP)Pc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Snca/EGFP)Pc}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Peng Cao
• MGI ID: MGI:8327603
• Synonyms: RCL-Snca-6H-EGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Snca/EGFP)Pc} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details:

  Using the CRISPR/Cas9 system, the Snca-6H-EGFP cDNA sequence was inserted into intron 1 of the Gt(ROSA)26Sor gene driven by CAG promoter. Loxp-STOP-Loxp sequence is placed in between CAG promoter and the Snca-6H-EGFP cassette, such that CRE recombination is needed to express the Snca-6H-EGFP. (J:383651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:383651 Zhang L, et al., Genetically encoded fluorescent reporters to visualize alpha-synuclein pathology in live brain. Cell. 2026 Apr 2;189(7):2108-2127.e21
• All: 1 reference(s)