Gt(ROSA)26Sor^{em1(Egln3)Jlob}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(Egln3)Jlob}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jose Lopez-Barneo
• MGI ID: MGI:8319128
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(Egln3)Jlob} page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details:

  This allele has a loxP-flanked STOP sequence followed by the murine cDNA (GenBank: AJ310548.1) linked to an IRES-GFP reporter element inserted into the locus. Gene expression is driven by the Gt(ROSA)26Sor promoter by capture of the endogenous transcript via a splice acceptor site. When bred to mice expressing cre recombinase, the STOP sequence is deleted, allowing the transcription and expression of EGLN3 and GFP. (J:367447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:367447 Sanchez-Garcia MA, et al., Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer's disease progression. Sci Adv. 2025 May 30;11(22):eadu2244
• All: 1 reference(s)