Tie1^em2Kaali
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tie1^em2Kaali
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; endonuclease-mediated mutation 2, Kari Alitalo
• MGI ID: MGI:8318847
• Synonyms: Tie1^M1106R
• Gene: Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
• Alliance: Tie1^em2Kaali page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using the CRISPR/Cas9 technique, three point mutations were introduced in exon 22 of the gene. One of these mutations was designed to cause an amino acid substitution at codon 1106, changing methionine (Met) to arginine (Arg). The other two mutations were silent with respect to the encoded amino acid residues. (J:351095)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tie1 Mutation: 70 strains or lines available

References

• Original: J:351095 Brouillard P, et al., Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema. J Clin Invest. 2024 May 30;134(14)
• All: 1 reference(s)