Ercc4^tm1.1Ggar
Targeted Allele Detail

Summary

• Symbol: Ercc4^tm1.1Ggar
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 4; targeted mutation 1.1, George Garinis
• MGI ID: MGI:8317142
• Synonyms: avXpf⁺
• Gene: Ercc4 Location: Chr16:12927548-12968481 bp, + strand Genetic Position: Chr16, 8.93 cM
• Alliance: Ercc4^tm1.1Ggar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246103
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: Knock-in mice (avXpf) expressing the NER structure-specific endonuclease XPF fused carboxy terminally, before the stop codon of the last exon 11, with a 15-amino-acid tandem affinity purification (TAP) tag biotinylatable Avi sequence and a 3x Flag tag separated by a tobacco etch virus (TEV) protease cleavage site. Recombination removed the floxed selection cassette. (J:246103)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ercc4 Mutation: 96 strains or lines available

References

• Original: J:246103 Chatzinikolaou G, et al., ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017 May;19(5):421-432
• All: 2 reference(s)