Ccl17^{tm1.1(HBEGF)Irfo}
Targeted Allele Detail

Summary

• Symbol: Ccl17^{tm1.1(HBEGF)Irfo}
• Name: C-C motif chemokine ligand 17; targeted mutation 1.1, Irmgard Forster
• MGI ID: MGI:8316686
• Synonyms: CCL17^DTR
• Gene: Ccl17 Location: Chr8:95537081-95538664 bp, + strand Genetic Position: Chr8, 46.85 cM
• Alliance: Ccl17^{tm1.1(HBEGF)Irfo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:382782
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Ccl17^{tm1.1(HBEGF)Irfo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  monkey	HBEGF

• Mutation details: The simian diphtheria toxin receptor (DTR, now heparin binding EGF-like growth factor or HBEGF) is expressed under the control of the endogenous promoter. Flp-mediated recombination removed the selection cassette. (J:382782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl17 Mutation: 15 strains or lines available

References

• Original: J:382782 Eberhard J, et al., Ablation of CCL17-positive hippocampal neurons induces inflammation-dependent epilepsy. Epilepsia. 2025;66(2):554-568
• All: 1 reference(s)