Adcy5^em1Ics
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adcy5^em1Ics
• Name: adenylate cyclase 5; endonuclease-mediated mutation 1, Mouse Clinical Institute
• MGI ID: MGI:8316683
• Synonyms: Adcy5^em1(R419W)
• Gene: Adcy5 Location: Chr16:34975247-35126108 bp, + strand Genetic Position: Chr16, 24.71 cM, cytoband B-5
• Alliance: Adcy5^em1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:379378
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation (c.1255C>T ENSMUSG00000022840) responsible for the amino acid substitution of arginine with tryptophan at position 419 (R419W). (J:379378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy5 Mutation: 68 strains or lines available

References

• Original: J:379378 Yuan R, et al., Modulation of striatal cAMP levels: A key pathway in the treatment of hyperkinetic movement disorders. iScience. 2026 Feb 20;29(2):114457
• All: 1 reference(s)