Tmprss6^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Tmprss6^{tm1c(EUCOMM)Wtsi}
• Name: transmembrane serine protease 6; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:8297047
• Gene: Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
• Alliance: Tmprss6^{tm1c(EUCOMM)Wtsi} page
• IMPC: Tmprss6 gene page

Mutation origin

• Mutant Cell Line: EPD0453_1_B07
• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details:

  The L1L2_Bact_P cassette was inserted at position 78345168 of Chromosome 15 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 78346006. Exon 3 is thus flanked by loxP sites. Using ES clone EPD0453_1_B07, the lacZ sequence and the neo cassette were removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 3 (ENSMUSE00000230171 in Tmprss6-201, GRCm39) floxed. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmprss6 Mutation: 47 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)