Lncpint^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Lncpint^tm1.1Ics
• Name: long non-protein coding RNA, Trp53 induced transcript; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:8280974
• Gene: Lncpint Location: Chr6:31070498-31195409 bp, - strand Genetic Position: Chr6, 12.56 cM
• Alliance: Lncpint^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:378332
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette was inserted upstream exon 1 and a second loxP site was inserted into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with the promoter region and exon 1 (ENSMUSE00000701712) (GRCm38, Lncpint-201) floxed. (J:378332)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lncpint Mutation: 9 strains or lines available

References

• Original: J:378332 Laugero N, et al., lncRNA LINC-PINT controls lymphatic function and inflammatory profile in lymphedema. Sci Adv. 2025 Dec 19;11(51):eaea2960
• All: 1 reference(s)