Prrx1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Prrx1^tm1.1Ics
• Name: paired related homeobox 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:8280696
• Synonyms: Prrx1^fl
• Gene: Prrx1 Location: Chr1:163072688-163141279 bp, - strand Genetic Position: Chr1, 70.53 cM
• Alliance: Prrx1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:372132
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP and an FRT site flanked neomycin resistance gene cassette site were inserted into intron 2. The Neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 2 (GRCm38, Prrx1-201 ENSMUSE00001331660) floxed. (J:372132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prrx1 Mutation: 33 strains or lines available

References

• Original: J:372132 Homps-Legrand M, et al., Uncovering an antifibrotic Prrx1-lineage mesenchymal cell subpopulation in fibrotic lungs. Dis Model Mech. 2025 Aug 1;18(8)
• All: 1 reference(s)