Ikzf4^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Ikzf4^tm1.1Ics
• Name: IKAROS family zinc finger 4; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:8280689
• Gene: Ikzf4 Location: Chr10:128466712-128505227 bp, - strand Genetic Position: Chr10, 77.11 cM, cytoband D3
• Alliance: Ikzf4^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:378076
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intro 7 and a second loxP site was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 8 (GRCm39, Ikfz4-201) floxed. (J:378076)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ikzf4 Mutation: 35 strains or lines available

References

• Original: J:378076 Polak K, et al., CD4(+) regulatory T cells lacking Helios and Eos. Biochem Biophys Res Commun. 2023 Jun 28;674:83-89
• All: 1 reference(s)