Il36a^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Il36a^tm1.1Ics
• Name: interleukin 36A; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:8280684
• Gene: Il36a Location: Chr2:24105429-24115713 bp, + strand Genetic Position: Chr2, 16.26 cM, cytoband A3
• Alliance: Il36a^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The following elements were inserted into intron 3 (Il36a-201, GCRm39): an FRT site, the En2 intron, sequence coding for F2A self-cleaving peptide, 3X SV40 NLS sequence, mScarlet reporter gene cDNA, SV40 poly(A) signal sequences, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site. A third loxP site was inserted into intron 4. This is a knockout allele that expresses the reporter gene. A conditional-ready allele, with floxed exon 4, can be created through subsequent Flp-mediated removal of the selection and reporter cassettes. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il36a Mutation: 12 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)