Tectb^em1Guru
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tectb^em1Guru
• Name: tectorin beta; endonuclease-mediated mutation 1, Channabasavaiah Gurumurthy
• MGI ID: MGI:8277171
• Synonyms: Tectb-C225Y
• Gene: Tectb Location: Chr19:55169165-55184745 bp, + strand Genetic Position: Chr19, 51.13 cM
• Alliance: Tectb^em1Guru page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details:

  A guide RNA (TGTCTCATCGGTGGGGC/AGCTGG) in antisense orientation was used to create a TGC to TAC mutation in codon 225 of the tectorin beta (Tectb) gene, resulting in a cysteine to tyrosine mutation (C225Y) that corresponds to the human variant found in autosomal dominant, non-syndromic hearing loss based on Tectb-201 ENSMUST00000025936.12. (J:101977, J:377630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tectb Mutation: 48 strains or lines available

References

• Original: J:377630 Hale EB, et al., The TECTB-C225Y Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice. medRxiv. 2025 Aug 14
• All: 2 reference(s)