Gt(ROSA)26Sor^{tm3(EWSR1/CREB3L1)Cklr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(EWSR1/CREB3L1)Cklr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Charles Keller
• MGI ID: MGI:8270521
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(EWSR1/CREB3L1)Cklr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(EWSR1/CREB3L1)Cklr} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CREB3L1 (90993)

  Creb3l1

  (MGI:1347062)

  human

  EWSR1 (2130)

  Ewsr1

  (MGI:99960)

• Mutation details:

  The allele contains (from 5' to 3') a loxP site, a neomycin resistance (neo) cassette, a lox2272 site, a human Ewing sarcoma breakpoint region 1 fusion (EWSR1) cDNA fused to a human cAMP responsive element binding protein 3-like 1 (CREB3L1) cDNA with a polyadenylation signal, and second loxP and lox2272 sites in opposite orientations to their companion lox sites. The EWSR1::CREB3L1 fusion sequence is inserted in opposite orientation to the endogenous Gt(ROSA)26Sor gene. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)