Gt(ROSA)26Sor^{tm1(WDFY3)Ayama}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(WDFY3)Ayama}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ai Yamamoto
• MGI ID: MGI:8257028
• Synonyms: Rosa^flox-hAlfy
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(WDFY3)Ayama} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:373754
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(WDFY3)Ayama} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  WDFY3 (23001)

  Wdfy3

  (MGI:1096875)

• Mutation details:

  The targeting vector was designed to insert a loxP-flanked NEO-stop cassette, containing a splice acceptor and a floxed PGK/gb2neoPGKpolyA2XSV40pA cassette, the human WD repeat and FYVE domain containing 3 (WDFY3) cDNA sequence, fused to a 3xFLAG tag, into the Gt(ROSA)26Sor locus. (J:101977, J:373754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:373754 Croce KR, et al., A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy. Neuron. 2025 Sep 12
• All: 2 reference(s)