Tcf4^tm1.1Yxie
Targeted Allele Detail

Summary

• Symbol: Tcf4^tm1.1Yxie
• Name: transcription factor 4; targeted mutation 1.1, Yunli Xie
• MGI ID: MGI:8245452
• Synonyms: Tcf4^floxP
• Gene: Tcf4 Location: Chr18:69476500-69821038 bp, + strand Genetic Position: Chr18, 43.23 cM, cytoband E2
• Alliance: Tcf4^tm1.1Yxie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316579
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details:

  The targeting construct floxed the fragment containing the bHLH exon and the 3' exons. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:316579)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf4 Mutation: 66 strains or lines available

References

• Original: J:316579 Wang Y, et al., Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration. Cereb Cortex. 2020 May 14;30(5):3102-3115
• All: 4 reference(s)