Mllt1^em1Wenh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mllt1^em1Wenh
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; endonuclease-mediated mutation 1, Hong Wen
• MGI ID: MGI:8242304
• Synonyms: Enl^T1-fl
• Gene: Mllt1 Location: Chr17:57199611-57242497 bp, - strand Genetic Position: Chr17, 29.56 cM, cytoband E1.1
• Alliance: Mllt1^em1Wenh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details:

  CRISPR-targeting of inserted a loxP site upstream of the endogenous exon 4 and fused the remaining sequencing sequence in frame following by a loxP site and a modified exon 4 (T1 modification of the YEATS domain NPPVNHLR to NPPVNHLNHLR). This allele mimics a mutation found in Wilms tumors from patients. (J:363737)

• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt1 Mutation: 21 strains or lines available

References

• Original: J:363737 Xue Z, et al., Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development. Nat Commun. 2025 Mar 14;16(1):2531
• All: 1 reference(s)