Fbn1^tm1(FBN1)Cya
Targeted Allele Detail

Summary

• Symbol: Fbn1^tm1(FBN1)Cya
• Name: fibrillin 1; targeted mutation 1, Cyagen Biosciences
• MGI ID: MGI:8235563
• Synonyms: Fbn1^tm1(hFBN1)
• Gene: Fbn1 Location: Chr2:125142514-125348417 bp, - strand Genetic Position: Chr2, 61.38 cM, cytoband F
• Alliance: Fbn1^tm1(FBN1)Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Fbn1^tm1(FBN1)Cya expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FBN1 (2200)

  Fbn1	(MGI:95489)

• Mutation details:

  The sequence from amino acid 25 to ~600 bp downstream of the 3'UTR of mouse Fbn1 was replaced with the sequence from amino acid 25 to ~600 bp downstream of the 3'UTR of human FBN1. The murine signal peptide (amino acid 1~24) was kept. (J:326541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn1 Mutation: 177 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)