Ctnnd2^{em1(HBEGF)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctnnd2^{em1(HBEGF)Cya}
• Name: catenin delta 2; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:8235547
• Synonyms: Ctnnd2^{em1(P2A-tdTomato-IRES-LSL-DTR)}
• Gene: Ctnnd2 Location: Chr15:30172739-31029487 bp, + strand Genetic Position: Chr15, 12.02 cM
• Alliance: Ctnnd2^{em1(HBEGF)Cya} page

Mutation origin

• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Ctnnd2^{em1(HBEGF)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  monkey	HBEGF

• Mutation details:

  The TAA stop codon was replaced with the P2A-tdTomato-IRES-loxP-6xSV40 pA loxP-DTR cassette. Upstream of the DTR (diphtheria toxin receptor) gene lies a loxP-Stop-loxP cassette that blocks DTR transcription and expression. In the absence of Cre recombinase, the Ctnnd2 promoter drives tdTomato expression, labeling Ctnnd2-positive cells with red fluorescence. Upon Cre recombination, Cre-mediated deletion of the loxP-flanked stop (LSL) element enables DTR expression in Cre-positive cells. Intravenous administration of diphtheria toxin (DT) then selectively ablates these cells. (J:326541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnd2 Mutation: 66 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)