Tg(HLA-DR3,HLA-DQ2)303Jmcc
Transgene Detail

Summary

• Symbol: Tg(HLA-DR3,HLA-DQ2)303Jmcc
• Name: transgene insertion 303, James McCluskey
• MGI ID: MGI:8209415
• Synonyms: HLA-DR3-DQ2, Tg(HLA DR3-DQ2)303
• Transgene: Tg(HLA-DR3,HLA-DQ2)303Jmcc Location: unknown
• Alliance: Tg(HLA-DR3,HLA-DQ2)303Jmcc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 320kb YAC DNA clone containing an intact region from HLA DRA to DQB2 was transfected into C57BL/6 ES cells. Two clones in which the relevant HLA loci had integrated into the ES genome without detectable deletion or rearrangement and which lacked yeast chromosome 3. A single founder was established. (J:126283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:126283 Chen Z, et al., A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice. J Immunol. 2002 Mar 15;168(6):3050-6
• All: 4 reference(s)