Tg(tetO-lacZ,-Gsk3b)G6Avil
Transgene Detail

Summary

• Symbol: Tg(tetO-lacZ,-Gsk3b)G6Avil
• Name: transgene insertion G6, J Avila
• MGI ID: MGI:8209198
• Synonyms: BiTetO Betagal/GSK-3beta
• Transgene: Tg(tetO-lacZ,-Gsk3b)G6Avil Location: unknown
• Alliance: Tg(tetO-lacZ,-Gsk3b)G6Avil page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(tetO-lacZ,-Gsk3b)G6Avil expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gsk3b (MGI:1861437)

• Tg(tetO-lacZ,-Gsk3b)G6Avil expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details:

  The construct consists of seven copies of the palindromic tet operator sequence flanked by two CMV promoter sequences in divergent orientations. This bi-directional promoter is followed by a Gsk3b cDNA sequence with a myc epitope at its 5'-end in one direction and beta-galactosidase (LacZ) sequence including a nuclear localization signal (NLS) in the other. Five transgenic lines were generated, and lines G6 and G7 were chosen for further analysis. (J:67070)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67070 Lucas JJ, et al., Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 2001 Jan 15;20(1-2):27-39
• All: 9 reference(s)