Gt(ROSA)26Sor^{em1(CAG-Sting1,-EGFP)Nyan}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Sting1,-EGFP)Nyan}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Nan Yan
• MGI ID: MGI:8187339
• Synonyms: LSL-Sting1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Sting1,-EGFP)Nyan} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details:

  Using CRISPR/Cas9 technology, a CAG-promoter-loxP-PGK-Neo-6* SV40 pA-loxP-Kozak-murine Sting1 CDS-IRES-EGFP-rBG pA cassette was introduced to the mouse Gt(ROSA)26Sor gene. (J:363480)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1243 strains or lines available

References

• Original: J:363480 Knox K, et al., Dynamic STING repression orchestrates immune cell development and function. Sci Immunol. 2025 Mar 7;10(105):eado9933
• All: 1 reference(s)