Egln1^{tm4.1(EGLN1*)Fsl}
Targeted Allele Detail

Summary

• Symbol: Egln1^{tm4.1(EGLN1*)Fsl}
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 4.1,Frank Lee
• MGI ID: MGI:8186458
• Synonyms: Phd2^Tib
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^{tm4.1(EGLN1*)Fsl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289921
• Parent Cell Line: EAP6 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Egln1^{tm4.1(EGLN1*)Fsl} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGLN1 (54583)

  Egln1

  (MGI:1932286)

• Mutation details: The targeting vector was designed to replace the endogenous exon 1 of the egl-9 family hypoxia-inducible factor 1 (Egln1) gene with a human exon 1 sequence that harbors a D4E/C127S double amino acid substitution. The targeting construct also consisted of a loxP-flanked neomycin selection cassette. The the floxed neomycin cassette was removed by Cre recombinase. (J:289921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 23 strains or lines available

References

• Original: J:289921 Song D, et al., Tibetan PHD2, an allele with loss-of-function properties. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12230-12238
• All: 1 reference(s)