Ptges3^em1Fsl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptges3^em1Fsl
• Name: prostaglandin E synthase 3; endonuclease-mediated mutation 1, Frank Lee
• MGI ID: MGI:8175651
• Synonyms: p23^AA, p23^L159A/E160A
• Gene: Ptges3 Location: Chr10:127894851-127913123 bp, + strand Genetic Position: Chr10, 76.39 cM
• Alliance: Ptges3^em1Fsl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing. Two guide RNAs (TAG GTC TTT CAG AGA TGC CAG ATC and AAA CGA TCT GGC ATC TCT GAA AGA) were used to introduce two (L159A/E160A) amino acid substitutions in the prostaglandin E synthase 3 (Ptge3) gene. (J:289921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptges3 Mutation: 43 strains or lines available

References

• Original: J:289921 Song D, et al., Tibetan PHD2, an allele with loss-of-function properties. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12230-12238
• All: 1 reference(s)