Zc4h2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Zc4h2^tm1.1Ics
• Name: zinc finger, C4H2 domain containing; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:8164208
• Gene: Zc4h2 Location: ChrX:94682799-94702115 bp, - strand Genetic Position: ChrX, 41.99 cM
• Alliance: Zc4h2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342743
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele was generated using the PG00049_W_3_C06 KOMP vector. The L1L2_Bact_P cassette was inserted into intron 1. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 (Zc4h2-201, GRCm39). Subsequent Flp-mediated recombination removed the lacZ and neo cassettes and left exon 2 floxed. (J:342743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zc4h2 Mutation: 3 strains or lines available

References

• Original: J:342743 Meziane H, et al., Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models. Biomedicines. 2022 Dec 6;10(12)
• All: 1 reference(s)