Rgs1^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rgs1^{tm1a(EUCOMM)Wtsi}
• Name: regulator of G-protein signaling 1; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:7867978
• Gene: Rgs1 Location: Chr1:144120407-144124862 bp, - strand Genetic Position: Chr1, 62.56 cM
• Alliance: Rgs1^{tm1a(EUCOMM)Wtsi} page
• IMPC: Rgs1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:361968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s). The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:361968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs1 Mutation: 23 strains or lines available

References

• Original: J:361968 Mary Lyon Centre at MRC Harwell, Direct data submission from Mary Lyon Centre at MRC Harwell. 2025
• All: 1 reference(s)