Tg(Tagln-Usp20*)1Shes
Transgene Detail

Summary

• Symbol: Tg(Tagln-Usp20*)1Shes
• Name: transgene insertion 1, Sudha Shenoy
• MGI ID: MGI:7865093
• Synonyms: SM22-HA-DN-USP20 Tg
• Transgene: Tg(Tagln-Usp20*)1Shes Location: unknown
• Alliance: Tg(Tagln-Usp20*)1Shes page

Transgene origin

• Strain of Origin: B6SJLF1/J

Transgene description

• Transgene Type: Transgenic (Dominant negative, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tagln-Usp20*)1Shes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Usp20 (MGI:1921520)	Dominant negative

• Tg(Tagln-Usp20*)1Shes expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tagln (MGI:106012)

• Mutation details: The mouse promoter drives smooth muscle-specific expression of a dominant negative mouse gene with an HA-tag and amino acid substitution C154S and H645Q in the catalytic domain of the protein. (J:232730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:232730 Jean-Charles PY, et al., Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation. J Biol Chem. 2016 Apr 1;291(14):7450-64
• All: 2 reference(s)