Kif5c^tm2.2Ics
Targeted Allele Detail

Summary

• Symbol: Kif5c^tm2.2Ics
• Name: kinesin family member 5C; targeted mutation 2.2, Mouse Clinical Institute
• MGI ID: MGI:7863641
• Gene: Kif5c Location: Chr2:49509310-49664790 bp, + strand Genetic Position: Chr2, 28.68 cM, cytoband C
• Alliance: Kif5c^tm2.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  Glutamic acid codon 237 (GAA) in exon 8 was changed to valine (GTA) (p.E237V). A loxP site, a neomycin resistance gene cassette, an FRT site flanked auto-excision protamine-cre cassette and a second loxP site were inserted into intron 8. Loss-of-function mutations in the human ortholog are associated with complex cortical dysplasia with other brain malformations 2 (CDCBM2). The knock-out allele was obtained after an additional breeding of the conditional allele with a cre recombinase deleter line. (J:342743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kif5c Mutation: 49 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 2 reference(s)