Is(7TOMM40,APOE_i4,APOC1)3.2Ics
Targeted Allele Detail

Summary

• Symbol: Is(7TOMM40,APOE_i4,APOC1)3.2Ics
• Name: insertion, Chr 7, Mouse Clinical Institute 3.2
• MGI ID: MGI:7863625
• Synonyms: ApoE^{tm1(TOMM40; APOE4; APOC1)Ics}
• Gene: Is(7TOMM40,APOE_i4,APOC1)3.2Ics Location: unknown

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Is(7TOMM40,APOE_i4,APOC1)3.2Ics involves 3 genes/genome features (Apoc1, Apoe, Tomm40) View all
• Is(7TOMM40,APOE_i4,APOC1)3.2Ics expresses 3 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOC1 (341)

  Apoc1

  (MGI:88053)

  human

  APOE (348)

  Apoe	(MGI:88057)

  isoform 4

  human

  TOMM40 (10452)

  Tomm40

  (MGI:1858259)

• Mutation details: The murine Tomm40, ApoE and Apoc1 28.2 kb region was replaced by a 34.2 kb human genomic sequence that contains TOMM40, APOE4 and APOC1. The floxed HygroR cassette and the flipped NeoR cassette were removed by 2 successive breeding steps. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Is(7TOMM40,APOE_i4,APOC1)3.2Ics Mutation: 1 strain or line available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)