Rr602^tm2.1Chalu
Targeted Allele Detail

Summary

• Symbol: Rr602^tm2.1Chalu
• Name: regulatory region 602; targeted mutation 2.1, James P Noonan
• MGI ID: MGI:7859533
• Gene: Rr602 Location: unknown Genetic Position: Chr1, Syntenic
• Alliance: Rr602^tm2.1Chalu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317994
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J-A^w-J/J

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Gbx2 enhancer (GRCm39:chr1:89641474-89642633), located in an Agap1 intron, was replaced with the orthologous chimpanzee enhancer (panTro6:chr2B:122441237-122442476). A loxP site flanked neomycin resistance gene cassette that was inserted was removed through subsequent Cre-mediated recombination. The chimpanzee enhancer drives Gbx2 expression in the embryonic fore- and hindlimb buds and other sites in a pattern similar to the endogenous mouse enhancer. (J:317994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr602 Mutation: 0 strains or lines available

References

• Original: J:317994 Dutrow EV, et al., Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome. Nat Commun. 2022 Jan 13;13(1):304
• All: 1 reference(s)