Rr381^em12Kap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr381^em12Kap
• Name: regulatory region 381; endonuclease-mediated mutation 12, Dietmar J. Kappes
• MGI ID: MGI:7858952
• Synonyms: QW82^-
• Gene: Rr381 Location: Chr3:89303454-89303824 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr381^em12Kap page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: The Zbtb7b silencer, located upstream, was targeted with a dsODN template using TALEN technology (ZFN target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG), resulting in the mutation of two EGR (E6, E7) binding sites and one Ebox (T6) motif. (J:320244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr381 Mutation: 0 strains or lines available

References

• Original: J:320244 Basu J, et al., An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol. 2022 Jan 21;5(1):84
• All: 1 reference(s)