Rr381^em11Kap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr381^em11Kap
• Name: regulatory region 381; endonuclease-mediated mutation 11, Dietmar J. Kappes
• MGI ID: MGI:7858951
• Synonyms: QK9^-
• Gene: Rr381 Location: Chr3:89303454-89303824 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr381^em11Kap page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: The Zbtb7b silencer, located upstream, was targeted with a dsODN template using TALEN technology (ZFN target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG), resulting in the mutation of one Ebox (T6) motif and three EGR (E6, E7, E9) and one NFAT (N5) binding sites. (J:320244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr381 Mutation: 0 strains or lines available

References

• Original: J:320244 Basu J, et al., An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol. 2022 Jan 21;5(1):84
• All: 1 reference(s)