Rr381^tm1(Rr96)Kap
Targeted Allele Detail

Summary

• Symbol: Rr381^tm1(Rr96)Kap
• Name: regulatory region 381; targeted mutation 1, Dietmar J. Kappes
• MGI ID: MGI:7857325
• Synonyms: ThPOK^CD4.Sil
• Gene: Rr381 Location: Chr3:89303454-89303824 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr381^tm1(Rr96)Kap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320244
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• The 418 bp Zbtb7b silencer, located upstream, was replaced with the 434 bp Cd4 silencer Rr96. (J:320244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr381 Mutation: 0 strains or lines available

References

• Original: J:320244 Basu J, et al., An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol. 2022 Jan 21;5(1):84
• All: 1 reference(s)