Rr96^{tm1.1(Rr381)Kap}
Targeted Allele Detail

Summary

• Symbol: Rr96^{tm1.1(Rr381)Kap}
• Name: regulatory region 96; targeted mutation 1.1, Dietmar J. Kappes
• MGI ID: MGI:7857323
• Synonyms: CD4^ThPOK.Sil
• Gene: Rr96 Location: Chr6:124862841-124863329 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr96^{tm1.1(Rr381)Kap} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320244
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 434 bp Cd4 silencer, located in intron 1, was deleted and replaced with the 418 bp Zbtb7b silencer Rr381. (J:320244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr96 Mutation: 0 strains or lines available

References

• Original: J:320244 Basu J, et al., An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol. 2022 Jan 21;5(1):84
• All: 1 reference(s)