Galc^tm1.1Abss
Targeted Allele Detail

Summary

• Symbol: Galc^tm1.1Abss
• Name: galactosylceramidase; targeted mutation 1.1, Aimee Stablewski
• MGI ID: MGI:7857314
• Synonyms: Galc floxed
• Gene: Galc Location: Chr12:98168553-98225718 bp, - strand Genetic Position: Chr12, 49.83 cM
• Alliance: Galc^tm1.1Abss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to surround exon 9. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:296853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galc Mutation: 46 strains or lines available

References

• Original: J:296853 Weinstock NI, et al., Brainstem development requires galactosylceramidase and is critical for pathogenesis in a model of Krabbe disease. Nat Commun. 2020 Oct 23;11(1):5356
• All: 5 reference(s)