Hcrtr1^tm1.1Stak
Targeted Allele Detail

Summary

• Symbol: Hcrtr1^tm1.1Stak
• Name: hypocretin (orexin) receptor 1; targeted mutation 1.1, Takeshi Sakurai
• MGI ID: MGI:7857156
• Synonyms: OX1R-flox
• Gene: Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
• Alliance: Hcrtr1^tm1.1Stak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 5 and 6. The selection cassette was removed via FLP-mediated recombination in the germline. (J:255134)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcrtr1 Mutation: 33 strains or lines available

References

• Original: J:255134 Soya S, et al., Orexin modulates behavioral fear expression through the locus coeruleus. Nat Commun. 2017 Nov 20;8(1):1606
• All: 1 reference(s)