Zbtb20^tm1Sant
Targeted Allele Detail

Summary

• Symbol: Zbtb20^tm1Sant
• Name: zinc finger and BTB domain containing 20; targeted mutation 1, Derek Sant Angelo
• MGI ID: MGI:7857155
• Synonyms: Zbtb20^flox
• Gene: Zbtb20 Location: Chr16:42728008-43462981 bp, + strand Genetic Position: Chr16, 28.44 cM, cytoband B4
• Alliance: Zbtb20^tm1Sant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:356603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 14 was flanked by loxP sites. Upon Cre-mediated recombination exon 14 (transcript: Zbtb20-204 ENSMUST00000114694.8) is deleted, resulting in a Zbtb20 protein lacking 535 central residues, including the BTB/POZ domain and the first Zn finger. (J:356603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb20 Mutation: 56 strains or lines available

References

• Original: J:356603 Krzyzanowska AK, et al., Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis. Sci Immunol. 2022 May 6;7(71):eabf3717
• All: 1 reference(s)