Kdm6b^tm1.2Fwin
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.2Fwin
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.2, Floriana Winau
• MGI ID: MGI:7857154
• Synonyms: JMJD3-KO
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.2Fwin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240632
• Parent Cell Line: CJ9 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 17-19. The neomycin selection cassette was deleted in the germline via FLP-mediated recombination and exons 17-19 were deleted by cre-mediated recombination. (J:240632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:240632 Beyaz S, et al., The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017 Feb;18(2):184-195
• All: 1 reference(s)