Osr1^tm1.1Sass
Targeted Allele Detail

Summary

• Symbol: Osr1^tm1.1Sass
• Name: odd-skipped related transcription factor 1; targeted mutation 1.1, David Sassoon
• MGI ID: MGI:7856800
• Synonyms: Osr1^fl
• Gene: Osr1 Location: Chr12:9624442-9631500 bp, + strand Genetic Position: Chr12, 4.05 cM
• Alliance: Osr1^tm1.1Sass page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336858
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The multifunctional parental allele which harbors a LacZ expression cassette followed by frt, loxP sites, an inverted exon 2, dre and frt sites, and inverted EGFP gene, dre, loxP and rox sites, was converted to a conditional ready loxP-flanked exon 2 allele by Flp/Frt recombination. (J:336858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Osr1 Mutation: 18 strains or lines available

References

• Original: J:336858 Vallecillo-Garcia P, et al., A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity. 2023 Jun 13;56(6):1204-1219.e8
• All: 1 reference(s)