Osr1^tm1Sass
Targeted Allele Detail

Summary

• Symbol: Osr1^tm1Sass
• Name: odd-skipped related transcription factor 1; targeted mutation 1, David Sassoon
• MGI ID: MGI:7856799
• Synonyms: Osr1^lacZ
• Gene: Osr1 Location: Chr12:9624442-9631500 bp, + strand Genetic Position: Chr12, 4.05 cM
• Alliance: Osr1^tm1Sass page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350768
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This multifunctional allele harbors a LacZ expression cassette followed by frt, loxP sites, an inverted exon 2, dre and frt sites, and inverted EGFP gene, dre, loxP and rox sites, which replaced exon 2 of the Osr1 coding sequence. The multifunctional allele can be converted to a LacZ-expressing null allele via Dre/Rox recombination, and to a conditional loxP-flanked allele via Flp/Frt recombination. (J:350768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Osr1 Mutation: 18 strains or lines available

References

• Original: J:350768 Stumm J, et al., Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury. Stem Cell Res. 2018 Oct;32:8-16
• All: 2 reference(s)