Tg(CD4-Tcrb)1Bnlt
Transgene Detail

Summary

• Symbol: Tg(CD4-Tcrb)1Bnlt
• Name: transgene insertion 1, Bart Lambrecht
• MGI ID: MGI:7856630
• Synonyms: 1DER, 1-DERbeta
• Transgene: Tg(CD4-Tcrb)1Bnlt Location: unknown
• Alliance: Tg(CD4-Tcrb)1Bnlt page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: cDNAs encoding productively rearranged V4 and V4 chains were cloned from a Derp-1-specific hybridoma cell line. The TCRV and V cDNAs were cloned into human CD4 promoter with silencer and human CD4 promoter expression vectors. These were coinjected to pronuclei of zygotes, but recovered mice express only the rearranged TCRbeta chain. (J:193483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:193483 Plantinga M, et al., Conventional and Monocyte-Derived CD11b(+) Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen. Immunity. 2013 Feb 21;38(2):322-35
• All: 4 reference(s)