Sox17^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Sox17^tm1.1Itl
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1.1, InGenious Targeting Laboraory
• MGI ID: MGI:7855939
• Synonyms: Sox17^flox
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296750
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 4 and 5, which encode the entire Sox17 coding region, are flanked by loxP sites and an frt-flanked neomycin selection cassette. The Neo cassette was excised by breeding with transgenic flipper mice ubiquitously expressing FLP recombinase. (J:296750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:296750 Chew LJ, et al., Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair. Cell Rep. 2019 Dec 3;29(10):3173-3186.e7
• All: 2 reference(s)