Ogt^em1Mbou
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ogt^em1Mbou
• Name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); endonuclease-mediated mutation 1, Mathieu Boulard
• MGI ID: MGI:7855909
• Synonyms: Ogt^em1(Y851A)
• Gene: Ogt Location: ChrX:100683666-100727957 bp, + strand Genetic Position: ChrX, 44.45 cM, cytoband D
• Alliance: Ogt^em1Mbou page

Mutation origin

• Strain of Origin: FVB/NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 19 (transcript Ogt-201, ENSEMBL v109; genomic coordinate: ChrX. 100719847100719886 (GRCm39/mm39)) produced the amino acid substitution of tyrosine with alanine at position 851 (Y851A). (J:360775)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogt Mutation: 11 strains or lines available

References

• Original: J:360775 Formichetti S, et al., Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo. PLoS Genet. 2025 Jan;21(1):e1011507
• All: 1 reference(s)