Hdac4^tm1.1Glas
Targeted Allele Detail

Summary

• Symbol: Hdac4^tm1.1Glas
• Name: histone deacetylase 4; targeted mutation 1.1, David J Glass
• MGI ID: MGI:7855758
• Synonyms: HDAC4^flox
• Gene: Hdac4 Location: Chr1:91856501-92123421 bp, - strand Genetic Position: Chr1, 46.24 cM
• Alliance: Hdac4^tm1.1Glas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283793
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by two loxP sites and an frt-flanked neomycin selection cassette in the adjacent introns. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. Upon Exon 5 deletion a frameshift mutation will occur causing premature termination of protein translation. (J:283793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac4 Mutation: 114 strains or lines available

References

• Original: J:283793 Luo L, et al., HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1alpha, and Hsc70. Cell Rep. 2019 Oct 15;29(3):749-763.e12
• All: 1 reference(s)