Nrg1^tm1.1Dtal
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1.1Dtal
• Name: neuregulin 1; targeted mutation 1.1, David A Talmage
• MGI ID: MGI:7855141
• Synonyms: Nrg1^tm1DatV/L, Nrg1tm1Dat V/L, V321L
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1.1Dtal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358341
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The knock-in germline V321L mutation (gtgttg) in mice Nrg1 gene was introduced into embryonic stem cells using a bacterial artificial chromosome (BAC) construct. Frt flanked neo cassette was removed by Flp recombinase. (J:358341)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 55 strains or lines available

References

• Original: J:358341 Rajebhosale P, et al., Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus. J Neurosci. 2024 Oct 23;44(43)
• All: 1 reference(s)