Gt(ROSA)26Sor^{tm1(CAG-GALNT2)Gew}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-GALNT2)Gew}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gerrit Wolters-Eisfeld
• MGI ID: MGI:7854998
• Synonyms: Rosa26^GalNT2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-GALNT2)Gew} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:360759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-GALNT2)Gew} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GALNT2 (2590)

  Galnt2

  (MGI:894694)

• Mutation details: The human GALNT2 coding sequence (Gene ID: 2590) was introduced within the Rosa26 locus via homologous recombination in embryonic stem cells. A floxed (lox511 flanked) transcriptional STOP cassette was incorporated between the GALNT2 coding sequence and the CAG promoter. (J:360759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:360759 Mercanoglu B, et al., GalNT2-mediated O-glycosylation affects pancreas development and function in mice. Sci Rep. 2024 Nov 30;14(1):29760
• All: 1 reference(s)