Rr279^tm1.1Low
Targeted Allele Detail

Summary

• Symbol: Rr279^tm1.1Low
• Name: regulatory region 279; targeted mutation 1.1, Malcolm J Low
• MGI ID: MGI:7853955
• Synonyms: delta1
• Gene: Rr279 Location: Chr12:3992029-3992614 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr279^tm1.1Low page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224010
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Hypothalamic neuron-specific Pomc enhancer nPE1, located upstream of Pomc, was deleted (579 bp) and a loxP site flanked neomycin resistance gene cassette was inserted upstream of the enhancer location. The neo cassette was removed through subsequent Cre-mediated recombination. (J:224010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr279 Mutation: 0 strains or lines available

References

• Original: J:224010 Lam DD, et al., Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. PLoS Genet. 2015 Feb;11(2):e1004935
• All: 4 reference(s)